When the Newton family take a vacation at a lakeside cabin in the mountains, they bring Beethoven and his pups with them.
Eventually George discovers the pups and reluctantly agrees to keep them. Knowing what their father George Newton's reaction might be to this unexpected addition to their family, the kids hide the pups in the basement where the three Newton children take turns with round the clock feedings. In the meantime, young Ted and Emily Newton have overheard Regina's terrible plans for the pups and decide to bring them home where they can care for them and where they will be safe. When Missy gives birth to four of Beethoven's pups, Regina, a vain women who hates animals, is all for drowning the pups until she finds out how much money they might be worth.
Missy's owners Regina and Grillo are divorcing and Regina is using custody of Missy to get more money from her husband who loves Missy very much. In this sequel to the hugely successful original, Beethoven falls in love with a beautiful St.